Carbonic anhydrase isozymes IX and XII in gastric tumors

Figure 2 Immunohistochemical staining of CA IX in normal gastric mucosa (A), metaplasia (B), adenoma with moderate dysplasia (C), adenocarcinoma grade II (D), adenocarcinoma grade III (E), and diffuse carcinoma (F). In the normal mucosa, CA IX was expressed in all histological layers covering the luminal surface (LS), proliferative zone (PZ), and gastric glands (G). It was notable that CA IX was confined to deep crypts in metaplastic epithelium. The adenoma sample and all malignant lesions shown in this figure were positive for CA IX. (Original magnifications × 200).