NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China

doi:10.3748/wjg.v9.i7.1390

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Jul 15, 2003 (publication date) through May 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Jul 15, 2003; 9(7): 1390-1393
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1390

Table 1 Demographic characteristics and NQO1 polymorphism among ESCC, GCA patients and controls

Groups	Control n (%)	ESCC n (%)	GCA n (%)
Sex
Male	109 (66.1)	124 (64.3)	92 (74.2)
Female	56 (33.9)	69 (35.7)	32 (25.8)
Mean age ± SD (yrs)	52 ± 7.16	59 ± 8.73	60 ± 8.24
Smoking status
Smoker	82 (49.7)	104 (53.9)	68 (59.8)
Non-smoker	83 (50.3)	89 (46.1)	46 (40.2)
Family history of UGIC
Positive	0	86 (44.6)	45 (36.3)
Negative	165 (100)	107 (55.4)	79 (63.7)
Genotype
C/C	52 (31.5)	51 (26.4)	40 (32.3)
C/T	86 (52.1)	92 (47.7)	55 (44.3)
T/T	27 (16.4)	50 (25.9)^a	29 (23.4)
Allele type
C	190 (57.6)	194 (50.3)	135 (54.4)
T	140 (42.4)	192 (49.7)^b	113 (45.6)

Note. ESCC: esophageal squamous cell carcinoma; GCA: gastric cardiac adenocarcinoma; NQO1: NAD(P)H: quinone oxidoreductase 1; UGIC: upper gastrointestinal cancer; a. The genotype frequency was significantly higher than that in healthy controls (χ² = 4.79, P = 0.028); b. The allele frequency was marginaly higher than that in healthy controls (χ² = 3.83, P = 0.05).

Citation: Zhang JH, Li Y, Wang R, Geddert H, Guo W, Wen DG, Chen ZF, Wei LZ, Kuang G, He M, Zhang LW, Wu ML, Wang SJ. NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China. World J Gastroenterol 2003; 9(7): 1390-1393
URL: https://www.wjgnet.com/1007-9327/full/v9/i7/1390.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i7.1390