Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocompetent rats

Figure 5 Time course of ALT. To detect possible liver damage following inoculation of HBV, aliquots of rat serum, 10 μl, were assayed for ALT spectrophotometrically as described in Materials and methods. All assays were performed in triplicate and results expressed as means ± SD in units of IU/L. Rats tolerized transplanted and inoculated with HBV, open triangles; rats inoculated with HBV, had a slight increase in ALT on the first day, solid squares; rats transplanted, but not inoculated with HBV, open squares.