Pharmacokinetics of radioimmunotherapeutic agent of direct labeling mAb 188Re-HAb18

Table 3 Pharmacokinetic parameters of ¹⁸⁸Re-HAb18 F(ab’)₂ in hepatoma-bearing nude mice

Parameter	Unit	Value	Standard error
C0	1 × 109 Bq·L-1	6.18	3.14E-01
Ke	h-1	0.30	2.88E-02
Vd	1 × 10-9 L·Bq-1	1.49
T1/2(Ke)	h	2.29
AUC	1 × 109 Bq·h·L-1	20.49
CL	1 × 10-3 L·h-1	0.45

CO: Concentration at zero time Ke: Elimination rate constant; Vd: Apparent volume of distribution T_1/2: Half-life time; AUC: Area under the curve CL: Clearance.