Pharmacokinetics of radioimmunotherapeutic agent of direct labeling mAb 188Re-HAb18

Table 1 Biodistribution of ¹⁸⁸Re-HAb18 F(ab’)₂ in hepatoma-bearing nude mice

Tissue	T(post-inj)/h	188Re-HAb18 F(ab’)2
		%ID·g-1(-x±s)	T/NT ratio
Tumor	1	3.01 ± 0.89	ND
	4	3.94 ± 0.82	ND
	18	3.43 ± 0.28	ND
	24	1.96 ± 0.43	ND
	48	0.99 ± 0.32	ND
Blood	1	4.58 ± 0.63	0.66
	4	1.83 ± 0.10	2.15
	18	0.21 ± 0.04	16.30
	24	0.18 ± 0.03	10.90
	48	0.05 ± 0.01	19.80
Heart	1	1.60 ± 0.38	1.88
	4	0.80 ± 0.10	4.92
	18	0.36 ± 0.03	9.53
	24	0.30 ± 0.02	6.53
	48	0.21 ± 0.03	4.71
Liver	1	2.07 ± 0.40	1.45
	4	1.57 ± 0.31	2.51
	18	0.77 ± 0.12	4.45
	24	0.66 ± 0.10	2.97
	48	0.47 ± 0.13	2.11
Spleen	1	1.22 ± 0.25	2.47
	4	0.91 ± 0.22	4.33
	18	0.47 ± 0.07	7.30
	24	0.45 ± 0.08	4.36
	48	0.41 ± 0.10	2.40
Lung	1	1.45 ± 0.23	2.08
	4	0.86 ± 0.29	4.58
	18	0.19 ± 0.04	18.10
	24	0.18 ± 0.04	10.90
	48	0.14 ± 0.05	7.07
Kidney	1	59.81 ± 14.52	0.05
	4	47.83 ± 12.87	0.08
	18	18.72 ± 4.94	0.18
	24	15.80 ± 0.99	0.12
	48	7.31 ± 2.10	0.13
Large	1	1.36 ± 0.38	2.21
intestine	4	0.93 ± 0.24	4.24
	18	0.57 ± 0.06	6.02
	24	0.45 ± 0.00	4.36
	48	0.18 ± 0.03	5.50
Small	1	1.61 ± 0.43	1.87
intestine	4	0.88 ± 0.29	4.24
	18	0.33 ± 0.05	10.40
	24	0.29 ± 0.05	6.76
	48	0.13 ± 0.05	7.62
Muscle	1	0.74 ± 0.29	4.07
	4	0.44 ± 0.12	8.95
	18	0.19 ± 0.08	18.10
	24	0.16 ± 0.06	12.25
	48	0.05 ± 0.02	19.80
Bone	1	1.03 ± 0.31	2.92
	4	0.68 ± 0.12	5.79
	18	0.31 ± 0.09	11.06
	24	0.27 ± 0.02	7.26
	48	0.16 ± 0.02	6.19

ND: not done