Update of preclinical and human studies of calcium and colon cancer prevention

Table 4 Calcium effects on colonic cell proliferation, differentia tion and cytotoxicity in human subjects

In vitro	References*
Decreased proliferation (2 mM)	Buset et al 1986
Decreased proliferation (2-4 mM)	Appleton et al 1988
Decreased proliferation (2 mM)	Arlow et al 1988
Decreased proliferation (2 mM)	Buset et al 1987
Decreased proliferation (2 mM)	Friedman et al 1989
Protected colonic cells against toxicity of bile acids and fatty acids (5 mM)	Buset et al 1989
Decreased growth of human colon cancer cell lines	Guo et al[27] 1990
Increased histone acetylation: cell differentiation (1-2 mM)	Boffa et al 1989

*Studies without reference numbers are found in[23].