Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice

doi:10.3748/wjg.v32.i7.115143

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2026; 32(7): 115143
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.115143

Table 6 Rates of positive detection for Helicobacter pylori in vaginally and cesarean section-delivered offspring, n (%)

Group		Vaginal delivery¹		Cesarean section¹		Vaginal delivery²		Cesarean section²		Vaginal delivery³		Cesarean section³
Group		Number of mice	Hp positive mice⁴	Number of mice	Hp positive mice	Number of mice	Hp positive mice	Number of mice	Hp positive mice	Number of mice	Hp positive mice	Number of mice	Hp positive mice
Modeling of vaginal infection with Candida	V1	4	1 (25.0)	4	3 (75.0)	9	0 (0)	6	1 (16.7)	10	2 (20.0)	6	1 (16.7)
	V2	4	2 (50.0)	6	3 (50.0)	7	2 (28.6)	9	0 (0)	7	2 (28.6)	10	0 (0)
	V3	4	1 (25.0)	6	2 (33.3)	7	4 (57.1)	10	4 (40.0)	8	1 (12.5)	10	2 (20.0)
	VC	2	0 (0)	4	0 (0)	3	0 (0)	5	0 (0)	3	0 (0)	6	0 (0)
	VN	4	0 (0)	4	0 (0)	9	0 (0)	6	0 (0)	8	0 (0)	6	0 (0)
Modeling of gastric infection with Candida	G1	5	0 (0)	3	2 (66.7)	9	4 (44.4)	5	0 (0)	7	3 (42.9)	4	3 (75.0)
	G2	4	1 (25.0)	4	2 (50.0)	11	4 (36.4)	7	1 (14.3)	9	5 (55.6)	5	1 (20.0)
	G3	4	2 (50.0)	4	2 (50.0)	9	2 (22.2)	11	5 (45.5)	7	0 (0)	12	4 (33.3)
	G4	4	2 (50.0)	4	1 (25.0)	7	3 (42.9)	7	2 (28.6)	4	2 (50.0)	6	1 (16.7)
	GC	4	0 (0)	3	0 (0)	13	0 (0)	7	0 (0)	7	0 (0)	5	0 (0)
	GN	4	0 (0)	4	0 (0)	6	0 (0)	6	0 (0)	3	0 (0)	7	0 (0)

¹0-week mice.

²3-week mice.

³6-week mice.

⁴If one of the samples among those obtained for the gastric mucosa, intestinal tissue, or intestinal contents of the offspring mice is positive for the Helicobacter pylori 16S rDNA or urease A gene, it is identified as a Helicobacter pylori-positive mouse.

Hp: Helicobacter pylori.

Full Size Table

Citation: Xu XL, Luo TT, Liu Q, Cui GZ, Wu DY, Wu XJ, Yang TX, Sun JC, Jian HF, Zhuo SW, Chen ZH. Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice. World J Gastroenterol 2026; 32(7): 115143
URL: https://www.wjgnet.com/1007-9327/full/v32/i7/115143.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i7.115143

Xu XL, Luo TT, Liu Q, Cui GZ, Wu DY, Wu XJ, Yang TX, Sun JC, Jian HF, Zhuo SW, Chen ZH. Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice. World J Gastroenterol 2026; 32(7): 115143 [PMID: 41694489 DOI: 10.3748/wjg.v32.i7.115143]

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