Prognostic value of postoperative CEA/CA19-9 positivity and elevation relative to preoperative levels in gastric cancer

Table 5 Univariate and multivariate logistic regression analyses for postoperative carcinoembryonic antigen elevation

Variables	Univariate analysis		Multivariable analysis
	OR (95%CI)	P value	OR (95%CI)	P value
T stage
T1, T2, T3	Reference		Reference
T4	2.142 (1.466-3.131)	< 0.001	0.942 (0.590-1.505)	0.802
N stage
N0, N1	Reference		Reference
N2	2.848 (1.742-4.657)	< 0.001	2.726 (1.590-4.675)	< 0.001
N3	10.526 (6.537-16.950)	< 0.001	6.603 (3.815-11.426)	< 0.001
Differentiation
Moderate, good	Reference		Reference
Poor	2.960 (2.029-4.320)	< 0.001	2.015 (1.284-3.163)	0.002
Vascular invasion
Negative	Reference		Reference
Positive	5.197 (3.490-7.739)	< 0.001	3.953 (2.506-6.235)	< 0.001
Post-CEA
Negative	Reference		Reference
Positive	4.073 (2.323-7.142)	< 0.001	2.296 (1.152-4.575)	0.018
Post-CA19-9
Negative	Reference		Reference
Positive	3.900 (1.966-7.736)	< 0.001	1.349 (0.584-3.114)	0.483
PNI
≥ 49.98	Reference		Reference
< 49.98	2.286 (1.574-3.320)	< 0.001	1.824 (1.149-2.896)	0.011
PLR
< 138.41	Reference		Reference
≥ 138.41	2.184 (1.526-3.126)	< 0.001	1.418 (0.904-2.223)	0.128

CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; PLR: Platelet to lymphocyte ratio; PNI: Prognostic nutritional index; OR: Odds ratio; CI: Confidence interval.