Prognostic value of postoperative CEA/CA19-9 positivity and elevation relative to preoperative levels in gastric cancer

Table 2 Univariate and multivariate Cox regression analyses for overall survival of patients with gastric cancer

Variables	Univariate analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex
Male	Reference		Reference
Female	1.17 (0.89-1.54)	0.265	1.03 (0.77-1.38)	0.822
Age
< 60	Reference		Reference
≥ 60	1.34 (1.02-1.75)	0.034	1.24 (0.94-1.64)	0.124
Clinical stage
I, II	Reference
III	4.00 (2.85-5.59)	< 0.001
T stage
T1, T2	Reference		Reference
T3	2.53 (1.36-4.71)	0.003	2.10 (1.02-4.33)	0.044
T4	5.44 (3.16-9.39)	< 0.001	3.98 (2.06-7.70)	< 0.001
N stage
N0, N1	Reference		Reference
N2	2.49 (1.75-3.54)	< 0.001	1.62 (1.12-2.34)	0.010
N3	4.33 (3.12-6.01)	< 0.001	1.56 (1.08-2.25)	0.017
Differentiation
Moderate, good	Reference		Reference
Poor	1.96 (1.49-2.59)	< 0.001	1.33 (0.98-1.80)	0.065
Vascular invasion
Negative	Reference		Reference
Positive	2.11 (1.61-2.77)	< 0.001	1.18 (0.88-1.58)	0.259
CEA elevation
No	Reference		Reference
Yes	4.21 (3.23-5.49)	< 0.001	2.71 (2.01-3.66)	< 0.001
CA19-9 elevation
No	Reference		Reference
Yes	3.28 (2.50-4.31)	< 0.001	2.84 (2.15-3.76)	< 0.001

CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; HR: Hazard ratio; CI: Confidence interval.