Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications

doi:10.3748/wjg.119467

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 14, 2026; 32(34): 119467
Published online Sep 14, 2026. doi: 10.3748/wjg.119467

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Figure 10 Integrated immune and metabolic actions of non-alcoholic fatty liver disease therapies on the spleen-liver axis. Statins and other non-alcoholic fatty liver disease therapies act on monocytes and Kupffer cells, dampening cytokine output and reshaping immune-metabolic signaling across the spleen-liver axis[207-209]. FXR: Farnesoid X receptor; GLP-1RA: Glucagon-like peptide-1 receptor; IL: Interleukin; PPAR: Peroxisome proliferator-activated receptor; TNF-α: Tumor necrosis factor alpha.

Citation: Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467
URL: https://www.wjgnet.com/1007-9327/full/v32/i34/119467.htm
DOI: https://dx.doi.org/10.3748/wjg.119467

Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467 [DOI: 10.3748/wjg.119467]

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