Depleting apolipoprotein C3 alleviates acute pancreatitis in hamsters but not in mice

Figure 1 Depletion of apolipoprotein C3 does not ameliorate caerulein-induced acute pancreatitis in mice. A: Experimental timeline: 8- to 9-week-old male mice received intraperitoneal injections of caerulein (50 μg/kg) once per hour for a total of 10 injections. Pancreatic tissues and blood samples were collected 24 hours after the first injection; B-D: Comparison of plasma triglyceride levels (B), amylase activity (C), and lipase activity (D) between wild type (WT) and apolipoprotein C3 knockout (ApoC3^-/-) mice, n = 4; E: Representative hematoxylin and eosin staining of pancreatic tissues from WT and ApoC3^-/- mice, with enlarged images shown below; F-I: Quantitative histological scoring of pancreatic tissue: Oedema (F), inflammation (G), necrosis (H), and total histology score (I) in WT and ApoC3^-/- mice, n = 4. Data are presented as the mean ± SEM. ^aP < 0.05, ^bP < 0.001. ApoC3: Apolipoprotein C3; AP: Acute pancreatitis; NS: Not significant; W: Week; WT: Wild type; ApoC3^-/-: Apolipoprotein C3 knockout; HE: Hematoxylin and eosin.