Endoscopic diagnosis of non-erosive reflux disease

Figure 5 Autofluorescence imaging and confocal laser endomicroscopy reveal distinct features of normal esophageal mucosa and non-erosive reflux disease[27,28]. A: Normal esophageal mucosa under autofluorescence imaging; B: Longitudinal purple lines visualized under autofluorescence imaging; C: Esophageal mucosal appearance in healthy controls under confocal laser endomicroscopy; D: Dilated intercellular spaces and increased, dilated intrapapillary capillary loops (arrow) in non-erosive reflux disease patients under confocal laser endomicroscopy. Descriptions of subfigures A and B (adapted from Luo et al[27]). Citation: Luo X, Guo XX, Wang WF, Peng LH, Yang YS, Uedo N. Autofluorescence imaging endoscopy can distinguish non-erosive reflux disease from functional heartburn: A pilot study. World J Gastroenterol 2016; 22: 3845-3851. Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc.; descriptions of subfigures C and D (adapted from Chu et al[28]). Citation: Chu CL, Zhen YB, Lv GP, Li CQ, Li Z, Qi QQ, Gu XM, Yu T, Zhang TG, Zhou CJ, Rui-Ji, Li YQ. Microalterations of esophagus in patients with non-erosive reflux disease: In-vivo diagnosis by confocal laser endomicroscopy and its relationship with gastroesophageal reflux. Am J Gastroenterol 2012; 107: 864-874. Copyright ©The American College of Gastroenterology 2012. Published by Wolters Kluwer Health, Inc. (Supplementary material).