Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses

Figure 1 Salidroside alleviated the clinical symptoms of dextran sulfate sodium salt-induced colitis. A: Schematic of the experimental procedures; B: Chemical structure of salidroside (Sal); C: Changes in body weight of mice; D: Changes in body weight loss of mice; E: Comparison of colon length in each group of mice; F: Hematochezia observed in mice from each group: Control group (F1); Dextran sulfate sodium salt (DSS)-induced colitis (DSS) group (F2); DSS-induced colitis + Sal treatment (DSS + Sal) group (F3); G: Disease activity index scores after Sal treatment. Data are shown as mean ± SEM (n = 8), P values were calculated using one-way analysis of variance with Tukey’s test for Figure 1D and F and two-way analysis of variance with Šídák’s multiple comparisons test for Figure 1C and H. ^aP < 0.05. ^bP < 0.01. DSS: Dextran sulfate sodium salt; Sal: Salidroside.