TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease

Figure 2 Cell communication analysis in nonalcoholic fatty liver disease. A: Differential gene expression analysis showing up- and down-regulated genes across all eight clusters. An adjusted P value < 0.01 is indicated in red, while an adjusted P value ≥ 0.01 is indicated in black; B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of genetic variations in hepatic sinusoidal endothelial cells; C: Gene Ontology enrichment analysis of genetic variations in hepatic sinusoidal endothelial cells; D: Analysis of TSC22D1 expression levels in hepatic sinusoidal endothelial cells and the strength of communication with other cell types; E: Different cells interact via the tumor necrosis factor-like weak inducer of apoptosis fibroblast growth factor-inducible 14 signaling pathway. NK: Nature killer; FC: Fold change; COVID-19: Corona virus disease 2019; MAPK: Mitogen-activated protein kinase; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene Ontology; BP: Biological process; CC: Cellular component; MF: Molecular function; 5’-UTR: 5’ untranslated region; mRNA: Message RNA.