Flotillin-1 promotes the progression of hepatocellular carcinoma by activating TFE3-mediated Golgi stress response via inhibition of mTORC1/2

Figure 1 Correlation analysis of flotillin-1 expression and prognosis of liver cancer. A and B: Western blot and semi-quantitative analysis of the expression of flotillin-1 (FLOT1) in hepatocellular carcinoma (HCC) and adjacent normal tissues with GAPDH as a reference. Values are expressed as mean ± SD (n = 5); C: Immunohistochemical staining analysis of FLOT1 in HCC and adjacent normal tissues. Correlation analysis between FLOT1 expression and prognostic survival in HCC patients via Kaplan-Meier plotter analysis; D: Overall survival; E: Tumor Immune Estimating Resource analysis; F: Progression-free survival; G and H: Expression distribution of the FLOT1 gene and transcription factor E3 gene in tumor tissues and normal tissues; I: Scatter plot and fitting line of Spearman correlation analysis between gene and gene expression. Each point in the figure represents a sample; the X-axis and Y-axis represent gene expression. Comparisons between the two groups were performed using the t-test. ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. FLOT1: Flotillin-1; HR: Hazard ratio; TFE3: Transcription factor E3.