Clinicopathological significance of histological diversity in gastric adenocarcinoma with primitive enterocyte phenotype: A methylation-driven aggressive entity

Figure 3 Prognostic significance of gastric adenocarcinoma with primitive enterocyte phenotype compared to other gastric cancer subtypes. A: Kaplan-Meier survival curves using our institutional cohort demonstrate significantly worse overall survival (OS) in gastric adenocarcinoma with primitive enterocyte phenotype patients vs conventional gastric cancer and conventional gastric cancer expressing primitive phenotypic markers; B: Stratified analysis across cohorts (in-house); C: Kaplan-Meier survival curves using The Cancer Genome Atlas data demonstrate significantly worse OS in gastric adenocarcinoma with primitive enterocyte phenotype patients vs conventional gastric cancer and conventional gastric cancer expressing primitive phenotypic markers; D: Stratified analysis across cohorts (The Cancer Genome Atlas showed no OS difference between hepatoid adenocarcinoma and gastric adenocarcinoma with enteroblastic differentiation (P = 0.081 and P = 0.318, respectively), supporting their shared clinicopathological spectrum. GAPEP: Gastric adenocarcinoma with primitive enterocyte phenotype; CGC: Conventional gastric cancer; CGC-P: CGC: Conventional gastric cancer expressing primitive phenotypic markers; HAC: Hepatoid adenocarcinoma; GAED: Gastric adenocarcinoma with enteroblastic differentiation.