Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases

Figure 6 Translocator protein expression is significantly increased in the mouse brain after dextran sodium sulfate treatment. A: For patients with Alzheimer's disease (AD), the AlzData database is utilized, which includes integrated analysis of gene expression profiles from 684 patients with AD and 562 control brain tissues. This analysis generates a comprehensive gene expression profile of brain tissues and a catalog of susceptibility genes associated with AD. Separate analyses are conducted for four distinct brain regions affected by AD, including the entorhinal cortex, hippocampus, temporal cortex, and frontal cortex. The results reveal a significant increase in translocator protein (TSPO) expression in the temporal cortex of patients with AD compared with healthy controls. In other brain regions, TSPO expression in patients with AD shows an increasing trend, although the differences do not reach statistical significance; B and C: Immunohistochemical staining for TSPO of representative sections from the brain of two groups (original magnification 200 ×), and the numbers of TSPO⁺ cells in each high-power field view are shown in the bar chart (^aP < 0.05); D: Representative [¹⁸F]DPA-714 uptake according to micro-PET-CT imaging in wild-type (WT) mice with H₂O those with DSS treatment. Brain [¹⁸F]DPA-714 uptake is higher in the WT mice with DSS treatment than in those with H₂O treatment. Regions of interest drawn in the brain tissue are showed as throng white arrows on each image; E: Statistical analysis and comparison of the brain standardized uptake value in WT mice with H₂O and those with DSS treatment are shown (^bP < 0.01). n: The biologically independent replicates used in the statistical analyses. AD: Alzheimer's disease; DSS: Dextran sodium sulfate; TSPO: Translocator protein; SUV: Standardized uptake value.