Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection

Figure 5 Representative computed tomography and pathological findings in patients with pancreatic cancer. A and B: A 64-year-old male with pancreatic head cancer (white arrow), lesion size approximately 4.38 cm in diameter, showing no evidence of vascular invasion or lymph node metastasis; C: Pathological section at 100 × magnification shows tumor cells scattered singly within fibrous connective tissue. TNM stage: T3N0M0 (stage IIA); D and E: A 68-year-old male with pancreatic head cancer (white arrow), lesion size approximately 4.0 cm in diameter, with a ring-enhancing metastatic lesion in the right liver lobe (orange arrow) and an enlarged gallbladder (orange arrowhead); F: Pathological section at 100 × magnification shows metastatic adenocarcinoma within trabecular liver tissue, characterized by atypical glandular structures and scattered tumor cells. TNM stage: T2NxM1 (stage IV); G: Serum exosomal hsa-let-7f-5p expression levels in patients with localized pancreatic cancer and those with metastasis were 09768 and 1.8632, respectively.