Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer

Figure 5 Correlation between histone deacetylases 10 and tumor microenvironment in The Cancer Genome Atlas database. A: Low expression of 4 immunomodulators (MHC, immunostimulators, chemokines and receptors) in high and low-histone deacetylases 10 (HDAC10) groups; B: Low stromal, immune, and ESTIMATE scores in high HDAC10 groups; C: HDAC10 expression positively correlated with tumor purity; D: Low infiltration level of common immune cells in high HDAC10 group; E: Correlation between HDAC10 expression and infiltration levels of tumor-infiltrating immune cells calculated by seven independent algorithms; F: Immunohistochemistry analysis showed that low expression of CD8a, CXCL9 and CXCL10 in high HDAC10 group. Scale bar, 100 μm; G: HDAC10 expression was negatively associated with critical steps in cancer-immunity cycle. ^aP < 0.001, ^bP < 0.01, ^cP < 0.05. NS: No significance; HDAC10: Histone deacetylases 10.