Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer

Figure 2 Histone deacetylases 10 was associated with clinicopathological characteristics and nomogram model construction. A: Differential analysis for histone deacetylases 10 (HDAC10) expression in patients with different age; B: Gender; C: High HDAC10 expression in high grade; D: Status; E: High levels of HDAC10 in advanced T stage; F: High HDAC10 expression in advanced N stage; G: High HDAC10 expression in advanced M stage; H: High levels of HDAC10 in advanced pathologic stage; I and J: Univariate Cox and multivariate Cox regression analysis for clinical factors and HDAC10 expression with overall survival (OS). Hazard ratio > 1 represented risk factors for survival and hazard ratio < 1 represented protective factors; K: Nomogram for predicting the 1-, 3-, and 5-year OS from CRC tissue microarray; L: Calibration curves for predicting 1-, 3-, and 5-year OS; M: Receiver operating characteristic curve for predicting 1-, 3-, and 5-year OS; N: Decision curve analysis based on nomogram better determine survival than only HDAC10. OS: Overall survival; HDAC10: Histone deacetylases 10; AUC: Area under the curve.