Evaluating luminal and post-operative Crohn’s disease activity on magnetic resonance enterography: A review of radiological disease activity scores

Table 1 Objective treatment targets endorsed by the selecting therapeutic targets in inflammatory bowel disease-II guidelines in adult patients with Crohn’s disease[1]

STRIDE-II treatment target[1]	Definition
Endoscopic response	> 50% reduction from baseline in CDEIS or SES-CD
Endoscopic healing/remission	CDEIS < 3 or SES-CD ≤ 2, and absence of ulceration
Biomarker normalisation	CRP < upper threshold of normal range; FCP < 250 μg/g
Adjunctive target
Transmural healing/remission	Lack of consensus definition of transmural outcomes; Adjunct to endoscopic outcomes assessed using cross-sectional imaging modalities (MRI, CT, IUS)

STRIDE-II: Selecting therapeutic targets in inflammatory bowel disease-II; CDEIS: Crohn’s disease endoscopic index of severity; SES-CD: Simple endoscopic score for Crohn’s disease; CRP: C-reactive protein; FCP: Faecal calprotectin; MRI: Magnetic resonance imaging; CT: Computed tomography; IUS: Intestinal ultrasound.