Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury

Figure 4 Paneth cells inhibit leucine-rich repeat-containing G protein-coupled receptor 5⁺ intestinal stem cells proliferation by the bone morphogenic protein 7-activin A receptor type 2B/bone morphogenic protein receptor type 1A pathway. A: CellChat analysis of Paneth-intestinal stem cells communication reveals upregulation of the bone morphogenic protein 7 (BMP7)-activin A receptor type 2B signaling pathway under rotavirus infection; B: Violin plot of the expression of Bmp7 in Paneth cells; C: Bmp7 expression of subclustered Paneth cells; D and E: Comparison of Bmp7 expression in uninfected and infected Paneth cells; F: Feature plots (left) and violin plots (right) of the expression of activin A receptor type 2B and BMP receptor type 1A pathway of uninfected and infected stem cells; G: The expression patterns of various BMP family members across intestinal epithelial cells subclusters; H: Comparison of BMP expression in uninfected and infected intestinal epithelial cells subclusters; I: Spatial transcriptomic analysis of BMP localization in intestinal epithelial tissue. RV: Rotavirus; BMP: Bone morphogenic protein; EEC: Enteroendocrine cell; TA: Transit-amplifying cells; Acvr2b: Activin A receptor type 2B; Bmpr1a: Bone morphogenic protein receptor type 1A.