Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury

Figure 2 Reduction of mature Paneth cells with an increased proportion of the kallikrein 1 cluster. A: The Paneth cell cluster in Figure 1B were re-clustered. Uniform manifold approximation and projection of combined subclustered Paneth cells from uninfected and infected mice; B: Expression of representative marker genes of subclustered Paneth cells; C: Enriched Gene Ontology terms for main clusters in Paneth cells; D: Uniform manifold approximation and projections of uninfected Paneth cells (left) vs infected Paneth cells (right); E: Quantification of percent cells per cluster (left) and difference in percent of uninfected and infected cells (right); F: Pseudotime trajectory analysis of uninfected Paneth cells (left) vs infected Paneth cells (right). UMAP: Uniform manifold approximation and projection; Lyz: Lysozyme; Klk: Kallikrein; GO: Gene Ontology.