Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization

Figure 1 Potential targets and network analysis of kushenol I in the treatment of ulcerative colitis. A: Structure of kushenol I (KSCI); B: Venn diagram showing potential gene targets; C and D: Protein-protein interaction network of KSCI in treating ulcerative colitis (UC); E: Gene Ontology analysis of KSCI in the treatment of UC; F: Enrichment analysis of KSCI in treating UC using Kyoto Encyclopedia of Genes and Genomes pathways; G: Compound-target-disease-pathway network illustrating the potential mechanisms of action of KSCI in the treatment of UC. AKT: Protein kinase B; IL: Interleukin; MAPK: Mitogen-activated protein kinase; PI3K: Phosphoinositide 3-kinase.