Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment

Figure 5 Leucine-rich repeat-containing 19 expression correlates with immune cell infiltration and immune checkpoint genes in colorectal cancer. A: Leucine-rich repeat-containing 19 (LRRC19) expression correlates with immune cell infiltration levels, showing positive correlations with B cells, T cells/natural killer (NK) cells, and CD4⁺ T cells, and negative correlations with macrophages, myeloid dendritic cells, γδ T cells, neutrophils, NK cells, and CD8⁺ T cells. A weak positive correlation is observed with regulatory T cells (Tregs); B: LRRC19 gene correlates significantly with immune checkpoint genes, particularly in colorectal cancer (CRC), showing significant correlations with cluster of differentiation 40 ligand (CD40 LG), galectin-9 (LGALS9), transmembrane and immunoglobulin domain containing 2 (TMIGD2), CD44, and cytotoxic T-lymphocyte associated protein 4 (CTLA4); C: LRRC19 expression correlates with immune-inflammatory pathways, with significant positive correlations in CRC for pathways like B cell receptor signaling, chemokine signaling, and T cell receptor signaling.