Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment

Figure 1 Colorectal cancer differentially expressed gene analysis. A: Sample gene expression heterogeneity (heatmap); B: Genome-wide expression changes (volcano plot); C: Representative differentially expressed gene (DEG) expression distribution (heatmap); D: DEG statistical significance with key genes; E: Common DEGs between GSE41328 and GSE23878; F: Core gene interactions [streamlined protein-protein interaction (PPI)]; G: Leucine-rich repeat-containing 19 (LRRC19) overlap in transmembrane receptors and PPI network; H: Potential microRNAs/long non-coding RNAs regulating LRRC19; I: LRRC19-positively correlated genes; J: LRRC19-negatively correlated genes; K: Positive correlation gene enrichment [Kyoto Encyclopedia of Genes and Genomes (KEGG)/Gene Ontology (GO)]; L: Negative correlation gene enrichment (KEGG/GO). FTR: Functional transmembrane receptor.