Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model

Figure 6 Gender differences in behavioral phenotypes of dibutyltin dichloride -induced chronic pancreatitis model. A and B: No gender difference was observed in mechanical pain sensitivity in experimental mice before and after chronic pancreatitis (CP); C and D: No gender differences were observed in heat pain sensitivity (C) and cold allodynia (D) in experimental mice before and after CP; E and F: No gender differences were observed in motor function (E) and autonomous activities (F) in experimental mice before and after CP; G: No gender differences were observed in emotional state in experimental mice before and after CP. n = 5 mice. Data are shown as mean ± SEM. Statistical comparisons were conducted with unpaired two-way analysis of variance (A-D) or one-way analysis of variance (E-G) with Sidak’s post hoc test. WT: Wild type; CKO: Conditional knockout; DBTC: Dibutyltin dichloride; EPM: Elevated plus maze.