Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism

Table 6 Comparison of magnetic resonance parameters between the control, carbon tetrachloride, and carbon tetrachloride + zebularine groups

Parameters	2 weeks				4 weeks				6 weeks
	Control	CCl4	CCl4 + zebularine	P value	Control	CCl4	CCl4 + zebularine	P value	Control	CCl4	CCl4 + zebularine	P value
T1pre (millisecond)	632.554 ± 91.474	783.493 ± 47.454	790.09 ± 57.283	1.000	650.917 ± 14.543	845.448 ± 98.6	694.370 ± 52.447	< 0.001	632.712 ± 27.834	934.073 ± 38.4291	760.6564 ± 61.1215	< 0.001
△T1	445.771 ± 91.877	657.431 ± 51.533	633.599 ± 72.49	1.000	445.996 ± 69.364	724.751 ± 102.433	584.67 ± 55.173	< 0.001	439.015 ± 53.865	816.836 ± 41.547	666.994 ± 64.864	< 0.001
T2 (millisecond)	24.54 ± 1.253	30.124 ± 2.269	29.9 ± 1.592	1.000	25.278 ± 1.473	33.544 ± 2.575	30.698 ± 1.582	0.12	25.777 ± 1.304	37.305 ± 1.547	34.641 ± 1.489	< 0.001
ADC (× 10-3, mm2/second)	1.397 ± 0.190	1.076 ± 0.129	1.271 ± 0.135	< 0.001	1.178 ± 0.099	1.028 ± 0.106	1.454 ± 0.147	0.012	1.388 ± 0.229	0.946 ± 0.043	1.164 ± 0.155	0.005

ADC: Apparent diffusion coefficient; CCl₄: Carbon tetrachloride. The P values for the carbon tetrachloride group, compared to the control group, were < 0.001 at all three time periods, therefore, the P values presented in Table 6 correspond specifically to comparisons between the liver fibrosis and treatment groups.