Nonlinear association between estimated plasma volume status and acute kidney injury in acute pancreatitis patients

Table 3 Multiple logistic regression analysis for estimated plasma volume status and acute kidney injury in acute pancreatitis population

	Non-adjusted model		Adjusted model 1		Adjusted model 2		Adjusted model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
D-ePVS, tertiles
T1	1.8 (1.25-2.57)	0.001	1.65 (1.13-2.41)	0.01	1.54 (1.04-2.29)	0.032	1.56 (1.01-2.41)	0.045
T2	Ref.		Ref.		Ref.		Ref.
T3	2.14 (1.51-3.05)	< 0.001	2.32 (1.61-3.35)	< 0.001	2.31 (1.57-3.38)	< 0.001	1.87 (1.2-2.91)	0.005
P for trend	0.236		0.043		0.028		0.469
KH-ePVS, tertiles
T1	1.36 (0.95-1.95)	0.089	1.28 (0.87~1.89)	0.211	1.18 (0.79-1.77)	0.414	1.11 (0.72-1.72)	0.629
T2	Ref.		Ref.		Ref.		Ref.
T3	1.94 (1.38-2.73)	< 0.001	1.83 (1.28-2.62)	0.001	1.4 (1.19-2.54)	0.004	1.51 (1-2.29)	0.05
P for trend	0.023		0.051		0.05		0.167

Kaplan-Hakim formula-based estimated plasma volume status of tertile 1: < -7.425; tertile 2: -7.425 to 2.669; tertile 3: ≥ 2.669. Duarte formula-based estimated plasma volume status of tertile 1: < 4.231; tertile 2: 4.231-5.358; tertile 3: ≥ 5.358. Model 1: Adjusted for age, sex and body mass index. Model 2: Adjusted for age, sex, body mass index, hypertension, diabetes mellitus, coronary heart disease, heart rate, respiratory rate and pulse oxygen saturation. Model 3: Adjusted for age, sex, hypertension, diabetes mellitus, coronary heart disease, heart rate, respiratory rate, pulse oxygen saturation, sequential organ failure assessment score, bedside index of severity in acute pancreatitis score, triglyceride, calcium, albumin, fasting plasma glucose, amylase, procalcitonin, C-reactive protein and white blood cell count. D-ePVS: Duarte formula-based estimated plasma volume status; KH-ePVS: Kaplan-Hakim formula-based estimated plasma volume status; OR: Odds ratio; CI: Confidence interval.