Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis

Figure 3 ELISA of the autoantibody RPL30 in autoantibody-negative primary biliary cholangitis and healthy control. A: Scatter plot diagram of the optical density value level with the RPL30 antibody in the antibody-negative primary biliary cholangitis group and health control group; B: Analysis of receiver operating characteristic with a cutoff value = 0.0708, sensitivity = 75%, and specificity = 100%; C: Histogram of RPL30 antibody-positive patients in the antibody-negative primary biliary cholangitis (anti-mitochondrial antibody, anti-mitochondrial E2 subunit antibody, anti-glycoprotein 210, anti-speckled protein 100) and the control groups. ^aP < 0.001, ^bP < 0.0001. PBC: Primary biliary cholangitis; HC: Healthy control group; OD: Optical density; AUC: Area under the receiver operating characteristic curve; TPR: True positive rate; FPR: False positive rate; CI: Confidence interval.