Predictive models and clinical manifestations of intrapulmonary vascular dilatation and hepatopulmonary syndrome in patients with cirrhosis: Prospective comparative study

Figure 4 Heatmap depicting the correlation between clinical parameters and biomarkers. A: The values are presented as Spearman’s correlation coefficient (r) for a sample of 320 runners. The colormap ranges from 1 to -1, with blue indicating the highest value and red indicating the lowest value; B: Heatmap of corresponding P values. The colormap ranges from 0 to 1, with blue representing the largest value and white representing the smallest value. White cells without numerical values indicate that the P value is smaller than 0.001, indicating a highly significant correlation. DBIL: Direct bilirubin; ICAM-1: Intercellular adhesion molecule-1; INR: International normalized ratio; MELD: Model for End-Stage Liver Disease; P(A-a)O₂: Alveolar-arterial oxygen gradient; PaO₂: Partial pressure of oxygen in arterial blood; PaCO₂: Partial pressure of carbon dioxide in arterial blood; PDGF-BB: Platelet-derived growth factor BB; PH: Potential of hydrogen; PT: Prothrombin time; PTA: Prothrombin time activity; S1P: Sphingosine 1 phosphate; SpO₂: Peripheral oxygen saturation; TBIL: Total bilirubin; TNF: Tumor necrosis factor; VCAM-1: Vascular cell adhesion molecule-1; VEGF-A: Vascular endothelial growth factor A; vWF: Von Willebrand factor.