Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma

doi:10.3748/wjg.v31.i11.102848

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Mar 21, 2025 (publication date) through Apr 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 102848
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.102848

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Figure 7 Apatinib inhibits liver cancer angiogenesis and suppresses glycolysis in vascular endothelial cells in vivo. A: Tumor growth curve of mice treated with apatinib and 1,3-dicaffeoylquinic acid; B: Tumor size after 21 days of treatment with apatinib and 1,3-dicaffeoylquinic acid in mice; C: Immunofluorescence staining of mouse tissues treated with apatinib and 1,3-dicaffeoylquinic acid; D: The contents of alpha-fetoprotein and CD44 in animal tissues were detected by enzyme linked immunosorbent assay. ^cP < 0.001. Apa: Apatinib; DA: Dicaffeoylquinic acid; SMA: Smooth muscle actin; PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; AFP: Alpha-fetoprotein.

Citation: Wu Y, Xie BB, Zhang BL, Zhuang QX, Liu SW, Pan HM. Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma. World J Gastroenterol 2025; 31(11): 102848
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/102848.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.102848