Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma

Figure 4 Apatinib inhibits tube formation, proliferation, and migration but induces apoptosis of vascular endothelial cells. A: Influence of diverse apatinib levels on the capability of vascular endothelial cells (VECs) to form tubes; B: How varying concentrations of apatinib influence the migration patterns of VECs; C: The role of different apatinib doses in altering the proliferation capacity of VECs; D: Annexin V/ propidium iodide staining indicates that apatinib treatment triggers apoptosis in human umbilical vein endothelial cells. ^aP< 0.05, ^bP < 0.01, ^cP < 0.001. Apa: Apatinib; HUVEC: Human umbilical vein endothelial cells; PI: propidium iodide; FITC: Fluorescein isothiocyanate.