Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

Table 3 Molecular pathways of non-alcoholic fatty liver disease-associated miRNA in teen-longitudinal assessment of bariatric surgery participants

miRNA	Target	Function
miR-122	SIRT-1[73]; FOXO3[74]	miR-122 downregulates SIRT-1 and induces steatosis and hepatic lipogenesis in NAFLD[73]; miR-122-5p inhibits FOXO3 to attenuate inflammatory response and oxidative stress damage in NAFLD[74]
miR-125b	TNFAIP3[79]	miR-125b targets TNFAIP3 and promotes the NF-κB-mediated inflammatory response in NAFLD[79]
miR-146a	MED1[75]	miR-146a targets MED1 and improves hepatic lipid and glucose metabolism in NAFLD[75]
miR-181a	PPARα[76]	miR-181a inhibits PPARα and aggravates lipid accumulation in hepatocytes[76]
miR-22	SIRT-1[78]	miR-22 targets SIRT-1 and inhibits gluconeogenesis[78]
miR-34a	TGF-β1/Smad3[80]	miR-34a-5p targets TGF-β1/Smad3 and inhibits liver fibrosis in hepatic stellate cells[80]
miR-375	RAC1[81]	miR-375 inhibits RAC1 and alleviates liver fibrosis[81]

FOXO3: Forkhead box O 3; SIRT-1: Sirtuin 1; TNFAIP3: Tumor necrosis factor alpha-induced protein 3; MED1: Mediator complex subunit 1; PPARα: Peroxisome proliferator-activated receptor-α; TGF-β1: Transforming growth factor-β1; Smad3: Mothers against decapentaplegic family 3; RAC1: Rac family small GTPase 1; NAFLD: Non-alcoholic fatty liver disease.