HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells

Table 2 Differential miRNA targets genes

miRNA_ID	Targets	n
hsa-miR-1269a	ADORA1, CPLX2, MECR, ADAR, EXTL2, NCKAP5L, ZXDC, HSF4, ENGASE, CEMP1, TMEM231, CREBBP, PLIN4, WIPF3, TRMT9B, FOXRED2, PTGER3, LTBP3, KCNK16, INAVA, RBM24, OTOA, CELF5, ATP8B3, IL6ST, CDIP1, TGIF2, POC1B-GALNT4, RIMS4, RHOBTB1, TRRAP, PASK, CDC20, STON2, TP53I11, CHRDL2, BTD, H6PD, ANLN, C12orf43, MYCN, BRD1, CRYGN KCNH3, ZNF618, NFAM1, MAST2, KY, DLAT, TPR, GALNT4, WASL, CDC25B, VPS9D1, ZFHX3, TMEM115, PATZ1, CCT8L2, PCLO, SOX8, ATP11A, CLUH, ELAC2, MRGBP, SMG9, ROBO3, VWA1, WDR82, ZNF696, C1QTNF6, ALPK2, GIPC3, SDK1, N4BP1, SLC39A3, KLF15, LYL1, LHX3, METTL25, LOC101927262, MLPH, DNAI1, GSTO2, ACSM1, GPBAR1, DGKD, LOC107986805, IQANK1, DAPK2, NLRC3, CHST8, EMID1, LOC112268219, ZNF331	93
hsa-miR-584-5p	DHDDS, IL4I1	2
hsa-miR-30c-2-3p	AK1, IGFBP3, PARP3, CT45A5, CTDSPL, FAM227A, CT45A1, CT45A3, CT45A6, GAB4, ELMSAN1, FAM160A2, ZNF30, EPHA10, ECE1, ZNF84, RAI14, CCDC166, CHAMP1, C6orf132, FREM3, THRA, TFR2, SYT7, CABLES1, NOL4L, GPR161, KIAA2012, ATG4D, KCNK9, SIPA1L1, ADAP1, CT45A8, CT45A9, CT45A7 , LOC79999, LOC388436, MAPK4, CCR1, PCDHB6, ARMC7, XXYLT1, SLC22A14, ZSCAN22, KCNS1, LOC643802, SETD1B, ELAVL3, CSPG4, CHST3, CRK, KCNA10, MPHOSPH10, SPEG, SF3B3, ATG4B, KCNV1, KLHL20, SUSD6, ZDHHC17, DNAH1, PCDHB5, YTHDF1, AJAP1, PCDHB10, PCDHB11, PCDHB12, PCDHB13, PCDHB14, PCDHB2, PCDHB3, PCDHB7, PCDHB9, PCDHB8, WRNIP1, PCDHB16, NSD1, NOL12, TREML2, LRRC3, HUWE1, PRPF38A, TP53RK, SAMD10, CT45A2, MT1E, MT1M, KCNK3, P4HA2, ZNF467, SLC28A3, LOC102724624, IL17REL, DOCK2, ZDHHC11, C8orf88, LOC107987099, SUOX	98
hsa-miR-193b-5p	OR8J3, SH3D19, RPS19, ABCF1, SLC35E2B, CITED2, DNAI2, SLC35E2A, KIF21B, ZNF541, CACHD1, BRD1, ZNF677, GPR83, DLC1, DLG2, GOT1, KCNQ4, CCPG1, PIK3R2, TIMM44, SEPHS2, NLGN4Y, TNXB, ARHGAP27, GALNT12, FHOD3, CIC, UBE2S, EAF1, RNASEH2B, RPH3AL, MIB2, COQ8A, CIB4, C11orf91, GAREM1	37
hsa-miR-146a-5p	EARS2, GPATCH11, GPAT3	3
hsa-miR-181a-2-3p	GCGR, EPN1, GTF2A1L, STON1-GTF2A1L, ARHGEF26, REXO4, TJP1, ATXN2, MIER2, PRSS8, COPB2, SF3A1, CLEC4E, KIF26A, INO80D, USP53, MIIP, WDR46	18
hsa-miR-483-5p	UBE3A, ZBTB16, DTX2, EPN1, MAMSTR, ESRRG, PABPC4, TTC39C, NFKBIL1, NONO, HOPX, ZNF701, DNAJC27, RBM14, MAP4K4, ARFGAP2, UBAP2, LOC403312, SHROOM2, PTK2, SEC16B, CRYZL2P-SEC16B, GCNT1, HDAC2, NOVA2, TIMP2, CNTNAP1, NEURL1, HOXA11, NHLH2, MUC3A, CLDN16, NR2E3, GPATCH1, TMEM33, CTC1, TIMM29, MFSD6L, PAN3, THNSL1, VPS9D1, NKAIN4, FAM172A, DTHD1, RNF112, HS3ST1, GRIN2D, GNG8, ADRM1, PRDM15, LOC285500, UNC5A, PRKAG3, ROBO1, RNF180, RNF39, C1QTNF4, TBX5, CD27, SRL, PRCD, LOC390937, ZNF273	62
hsa-let-7b-5p	HMGCR, TRPM3, FOXB2, WDR62, BUB1B-PAK6, CMKLR1, GPR85, DICER1, SPHK2, TRRAP, RAB18, SOX5, PFKFB1, PAK6, HDAC6, PDP2, DNASE1, TAF5, IFT172, ZNF589, SLC35B4, RIMKLA, OTOP1, KMT5C, ZNF546, LRTOMT	26
hsa-miR-92b-3p	RPL28, ST20, SOAT1, UBXN1, MFGE8, IREB2, AURKA, PIAS2, NTN4, HTD2, KDSR, TLK1, HINT3, DNHD1, ARID3A, MYO3A, IGDCC4, CEP170B, RGS6	19
hsa-miR-146b-5p	BBS12, MSH5, INTS4, LOC101929322	4