Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway

Figure 3 Clinical relevance of circ563 in hepatocellular carcinoma. To further delineate the role of circ563, hepatocellular carcinoma and paired tumor-adjacent tissues were subjected to real-time polymerase chain reaction. A-C: Enhanced circ563 expression in hepatocellular carcinoma (HCC) tissue was detected compared with that in tumor-adjacent tissues, in line with miR-148a-3p downregulation and metal-regulatory transcription factor-1 (MTF-1) upregulation; D-F: Correlation analyses indicated the relationships between circ563, miR-148a-3p, and MTF-1 expression in HCC. ^cP < 0.001. circRNA: Circular RNA; HCC: Hepatocellular carcinoma; MTF-1: Metal-regulatory transcription factor-1.