Application of extended criteria donor grafts in liver transplantation for acute-on-chronic liver failure: A retrospective cohort study

Table 5 Univariable and multivariable logistic analysis of risk factors for early allograft dysfunction

Variables	OR	Univariate analysis		OR	Multivariate analysis
		HR (95%CI)	P value		HR (95%CI)	P value
Donor characteristics
HBV (positive vs negative)	1.076	0.522-2.220	0.843
Death of trauma (yes vs no)	1.331	0.689-2.568	0.395
ECD (yes vs no)	2.953	1.497-5.826	0.002	2.712	1.286-5.720	0.009
Operation characteristics
Blood loss (L)	1.080	0.925-1.262	0.330
Anhepatic phase (min)	1.036	1.012-1.060	0.003	1.031	1.002-1.060	0.034
Operation time (h)	1.487	1.124-1.967	0.005	1.271	0.915-1.767	0.153
IFLT (yes vs no)	0.121	0.014-1.031	0.053	0.114	0.011-1.218	0.072
Recipient characteristics
BMI (> 30 vs ≤ 30)	0.779	0.187-3.244	0.732
MELD (> 30 vs ≤30)	1.455	0.753-2.812	0.265
OFs (> 2 vs ≤ 2)	0.861	0.327-2.264	0.761
WBC (× 109/L)	1.039	0.945-1.142	0.432
N/L	0.997	0.946-1.051	0.906
Hb (g/L)	1.006	0.990-1.022	0.444
GGT (U/L)	1.015	1.002-1.029	0.027	1.017	1.003-1.032	0.016
ALB (g/L)	1.052	0.984-1.126	0.139
ALT (U/L)	1.002	0.998-1.006	0.288
AST (U/L)	1.001	0.997-1.004	0.650
PLT (× 109/L)	1.001	0.992-1.010	0.800
Fib (g/L)	0.692	0.332-1.441	0.325

OR: Odds ratio; CI: Confidence interval; HBV: Hepatitis B virus; ECD: Extended criteria donor; BMI: Body mass index; IFLT: Ischemia-free liver transplantation; MELD: Model for end-stage liver disease; OFs: Organ failures; WBC: White blood cell; Hb: Hemoglobin; GGT: Gamma glutamyltransferase; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelets; Fib: Fibrinogen.