Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer

Figure 7 Immunohistochemistry analysis on Ki67 and cleaved caspase-3 markers on colitis-associated cancer-mice model. A: H&E staining, Ki67 and cleaved caspase-3 (CC-3) staining; B and C: Ki67 and CC-3 staining exhibited lower proliferative and higher apoptotic cells on the buparlisib-treated colitis-associated cancer (CAC) mice model compared to the untreated CAC mice. ^aP < 0.05 (compared to the control group); data are presented as mean ± SEM; one-way ANOVA was employed; n = 4-8. The red arrow showed the tumor area. Magnification is 100 ×. CAC: Colitis-associated cancer; CC-3: Cleaved caspase-3.