Feasibility and efficacy of endoscopic purse-string suture-assisted closure for mucosal defects induced by endoscopic manipulations

Table 5 Risk factors for delayed adverse events

Factors	Total (AE)	Odds ratio	95%CI	P value
Closure of defects
Incomplete	11 (6)	21.33	5.45-83.45	< 0.011
Complete	169 (9)	1
Location (%)
Fundus	79 (7)	1.13	0.39-3.26	0.82
Others	101 (8)	1
Defect size
≥ 3 cm	52 (8)	3.14	1.08-9.18	0.0391
< 3 cm	128 (7)	1
Morphology
Deep SMT	76 (6)	0.90	0.31-2.66	0.86
Others (superficial SMT and precancerous lesion)	104 (9)	1
Closure type
P-EPSS	63 (5)	0.92	0.30-2.83	1.00
C-EPSS	117 (10)	1
Intraoperative perforation
Yes	55 (7)	2.13	0.73-6.21	0.24
No	125 (8)	1
Dissection method
EFTR	36 (5)	2.16	0.69-6.78	0.19
Others (ESD and ESE)	144 (10)	1

¹Statistically significant.

SMT: Submucosal tumor; P-EPSS: Endoscopic pre-purse-string suture; C-EPSS: Conventional endoscopic purse-string suture; AE: Adverse event; ESD: Endoscopic submucosal dissection; ESE: Endoscopic submucosal excavation; EFTR: Endoscopic full-thickness resection.