Disease trends after Helicobacter pylori eradication based on Japanese nationwide claims and the health check-up database

Table 1 Incidence or prevalence of each disease by year from primary Helicobacter pylori eradication therapy

Year	Denominator (patient-year)	Average age	Upper gastrointestinal diseases			IBD	Allergy
			GERD	Barrett’s esophagus	Other upper gastrointestinal diseases
-10	1146497	48.9	2.31% (2.28%, 2.33%)	0.004% (0.002%, 0.005%)	11.45% (11.39%, 11.51%)	0.029% (0.026%, 0.032%)	17.5% (17.4%, 17.5%)
-9	1943505	50.1	2.55% (2.52%, 2.57%)	0.006% (0.005%, 0.008%)	11.10% (11.05%, 11.14%)	0.028% (0.025%, 0.030%)	20.0% (19.9%, 20.0%)
-8	2761765	51.3	2.75% (2.73%, 2.77%)	0.007% (0.006%, 0.008%)	10.57% (10.54%, 10.61%)	0.026% (0.024%, 0.028%)	21.3% (21.2%, 21.3%)
-7	3364755	52.5	3.02% (3.00%, 3.04%)	0.010% (0.009%, 0.011%)	9.89% (9.86%, 9.92%)	0.027% (0.025%, 0.029%)	23.1% (23.1%, 23.2%)
-6	4001760	53.7	3.18% (3.16%, 3.19%)	0.011% (0.010%, 0.012%)	9.27% (9.24%, 9.30%)	0.027% (0.025%, 0.028%)	24.4% (24.3%, 24.4%)
-5	4520587	54.9	3.38% (3.37%, 3.40%)	0.015% (0.014%, 0.016%)	8.67% (8.64%, 8.70%)	0.028% (0.026%, 0.029%)	25.7% (25.7%, 25.7%)
-4	4746859	55.9	3.48% (3.47%, 3.50%)	0.018% (0.017%, 0.019%)	7.54% (7.51%, 7.56%)	0.027% (0.025%, 0.028%)	27.4% (27.3%, 27.4%)
-3	4880888	56.9	3.58% (3.56%, 3.59%)	0.023% (0.022%, 0.024%)	6.50% (6.48%, 6.53%)	0.027% (0.026%, 0.028%)	28.8% (28.7%, 28.8%)
-2	5025747	57.9	3.80% (3.78%, 3.81%)	0.030% (0.028%, 0.031%)	6.04% (6.02%, 6.06%)	0.029% (0.027%, 0.030%)	30.3% (30.3%, 30.4%)
-1	4732998	58.8	11.01% (10.99%, 11.04%)	0.164% (0.161%, 0.168%)	19.31% (19.27%, 19.35%)	0.046% (0.044%, 0.048%)	33.7% (30.3%, 30.4%)
0	4892585	59.8	11.33% (11.30%, 11.36%)	0.223% (0.219%, 0.227%)	16.48% (16.45%, 16.51%)	0.053% (0.051%, 0.055%)	34.7% (34.7%, 34.8%)
1	4137930	61.0	3.84% (3.82%, 3.86%)	0.083% (0.080%, 0.086%)	0.15% (0.15%, 0.16%)	0.034% (0.032%, 0.036%)	35.0% (34.9%, 35.0%)
2	3344893	62.2	3.30% (3.28%, 3.32%)	0.080% (0.077%, 0.083%)	0.12% (0.12%, 0.13%)	0.030% (0.028%, 0.032%)	35.7% (35.7%, 35.8%)
3	2520763	63.4	2.98% (2.96%, 3.00%)	0.076% (0.072%, 0.079%)	0.10% (0.09%, 0.10%)	0.030% (0.028%, 0.032%)	36.7% (36.7%, 36.8%)
4	1900509	64.5	2.76% (2.74%, 2.78%)	0.076% (0.072%, 0.080%)	0.09% (0.08%, 0.09%)	0.028% (0.026%, 0.031%)	36.5% (36.4%, 36.6%)
5	1275881	65.4	2.51% (2.49%, 2.54%)	0.073% (0.069%, 0.078%)	0.07% (0.07%, 0.07%)	0.028% (0.025%, 0.031%)	38.6% (38.5%, 38.7%)

The prevalence of allergic diseases and incidence of the other diseases are shown with 95% confidence intervals (lower limit, upper limit). Year 0 is the year of primary eradication, and negative values represent years before primary eradication. The elapsed year from the eradication was calculated as the integer part of the difference in the year and the time of the eradication. If the difference was negative, the elapsed year was the integer part minus one, as in SAS, the integers of the negative numbers were rounded up. GERD: Gastroesophageal reflux disease; IBD: Inflammatory bowel disease.