Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance

Figure 3 Memory T helper 7/memory follicular T helper 7 cell subpopulation levels in ulcerative colitis mice. A: Typical flow cytometry patterns of the spleen CD4⁺ cells in the spleen; B: Typical flow cytometry patterns were observed in the spleen; C: Typical flow cytometry patterns and histograms in the spleen of CD4⁺ CCR7^- cells; D and E: CD4⁺ IL-7R⁺ (Th7) cells; F and G: CD4⁺ CXCR5⁺ IL-7R⁺ (Tfh7) cells; H and I: CD4⁺ CCR7^-IL-7R⁺ (mTh7) cells; J and K: CD4⁺ CCR7^-CXCR5⁺ IL-7R⁺ (mTfh7) cells. Data are expressed as the mean ± SD (n = 8). The differences were statistically significant when compared with the Ctrl group (^aP < 0.05, ^bP < 0.01). Differences were statistically significant with the dextran sulfate sodium group (^cP < 0.05, ^dP < 0.01). DSS: Dextran sulfate sodium. Cur: Curcumin; DSS: Dextran sulfate sodium.