Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance

Figure 1 Curcumin effectively improved the symptoms of dextran sulfate sodium-induced ulcerative colitis mice. A: Dextran sulfate sodium (DSS)-induced ulcerative colitis model replication and Cur administration; B: Body weight changes of mice from days 0 to 18; C: Disease activity indexes of mice in each group from days 0 to 18; D: Specific colonic lengths of mice in each group; E: Pathological sections of the colon of each group of mice (HE staining, 50 × magnification; scale bar = 100 μm); F: The colonic length of mice in each group on day 18; G: Colon weights of mice in each group on day 18; H: The colonic length/colonic weight of mice in each group on day 18; I: The colonic weight index of mice in each group on day 18; J: Pathological injury scores of mice in each group. Data are expressed as the mean ± SD (n = 8). The differences were statistically significant when compared with the Ctrl group (^aP < 0.05, ^bP < 0.01). Differences were statistically significant with the DSS group (^cP < 0.05, ^dP < 0.01). Cur: Curcumin; DSS: Dextran sulfate sodium.