Role of non-Helicobacter pylori gastric Helicobacters in helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma

Figure 2 Simplified scheme of antigen-induced transformation of normal marginal-zone B-cells into malignant cells. A: Polyclonal B cell expansion and a selection process; B: Antigen-dependent monoclonal expansion; C: Acquisition of genetic abnormalities and antigen-independent lymphomagenesis. The proliferation of B cells is primarily induced by the interaction between CD40 and CD40 Ligand, facilitated by antigen-activated reactive T cells. Additionally, cytokines play a role in driving this B-cell proliferation. The persistent proliferative state of these B cells, along with chronic inflammation, triggers additional oncogenic events. Ultimately, these events lead to the development of antigen-independent lymphoproliferation. NHPHs: Non-Helicobacter pylori gastric helicobacters; ROS: Reactive oxygen species; MZL: Marginal zone lymphoma; MALT: Mucosa-associated lymphoid tissue; H. pylori: Helicobacter pylori.