Antagonizing adipose tissue-derived exosome miR-103-hepatocyte phosphatase and tensin homolog pathway alleviates autophagy in non-alcoholic steatohepatitis: A trans-cellular crosstalk

Figure 5 The effect of adipose tissue-derived exosomes miR-103 on the development of non-alcoholic steatohepatitis in mice. A: The expression of miR-103 in the liver, serum, and adipose tissue; B: The results of ELISA to measure serum alanine aminotransferase, aspartate aminotransferase, total triglycerides, total cholesterol, superoxide dismutase, malondialdehyde, and H₂O₂; C: Hematoxylin and eosin staining of mice liver from different groups; D: Oil-red staining of mice liver from different groups. ^aP < 0.01 vs control; ^bP < 0.05 vs exosomes; ^cP < 0.01 vs exosomes. Exo: Exosomes; NC: Negative control; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TG: Total triglycerides; CHOL: Cholesterol; SOD: Superoxide dismutase; MDA: Malondialdehyde.