Antagonizing adipose tissue-derived exosome miR-103-hepatocyte phosphatase and tensin homolog pathway alleviates autophagy in non-alcoholic steatohepatitis: A trans-cellular crosstalk

Figure 1 The effect of miR-103 on the development of non-alcoholic steatohepatitis in mice. A: The results of ELISA to measure serum alanine aminotransferase (ALT), aspartate aminotransferase, total triglycerides, total cholesterol, superoxide dismutase, malondialdehyde, and H₂O₂; B: Hematoxylin and eosin staining of mice liver from different groups; C: Oil-red staining of mice liver from different groups; D: The expression of miR-103 in the liver, circulating exosomes, and adipose tissue-derived exosomes. ^aP < 0.01 vs control; ^bP < 0.01 vs model. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TG: Total triglycerides; CHOL: Cholesterol; SOD: Superoxide dismutase; MDA: Malondialdehyde.