Bile acids and their receptors: Potential therapeutic targets in inflammatory bowel disease

doi:10.3748/wjg.v29.i27.4252

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Jul 21, 2023 (publication date) through May 14, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2023; 29(27): 4252-4270
Published online Jul 21, 2023. doi: 10.3748/wjg.v29.i27.4252

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Figure 2 Emerging role of bile acids and their receptors. DCA: Deoxycholic acid; LCA: Lithocholic acid; CA: Cholic acid; CDCA: Chenodeoxycholic acid; isoLCA: Isolithocholic acid; isoalloLCA: Isoallolithocholic acid; 3-oxoLCA: 3-oxolithocholic acid; isoDCA: 3β-hydroxydeoxycholic acid; THDCA: Taurohyodeoxycholic acid; LPS: Lipopolysaccharide; FXR: Farnesoid X receptor; GPABR1: G protein-coupled bile acid receptor 1; PXR: Pregnane X receptor; VDR: Vitamin D receptor; RORγt: Retinoid-related orphan receptor γt; CAR: Costitutive androstane receptor; S1PR2: Sphingosine-1-phosphate receptor 2; Th17 cells: T helper 17 cells; Treg cells: Regulatory T cells; ILC3: Innate lymphocyte type 3; DCs: Dendritic cells; ISC: Intestinal stem cell; YBX-1: Y box binding protein 1; ACE2: Angiotensin-converting enzyme 2; NLRP3: The NACHT, LRR, and PYD domains-containing protein 3; mitoROS: Mitochondrial reactive oxygen species; EMT: Epithelial-mesenchymal transition; FAO: Fatty acid oxidation; PPARα: Peroxisome proliferator-activated receptor alpha; TLR4: Toll-like receptor 4; TJ: Tight junction; TEER: Trans-epithelial electrical resistance; TLR4: Toll-like receptor 4.

Citation: Long XQ, Liu MZ, Liu ZH, Xia LZ, Lu SP, Xu XP, Wu MH. Bile acids and their receptors: Potential therapeutic targets in inflammatory bowel disease. World J Gastroenterol 2023; 29(27): 4252-4270
URL: https://www.wjgnet.com/1007-9327/full/v29/i27/4252.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i27.4252