Current opinion on the regulation of small intestinal magnesium absorption

doi:10.3748/wjg.v29.i2.332

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 14, 2023; 29(2): 332-342
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.332

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Figure 5 P2Y₂ purinoceptors modulate intestinal magnesium absorption. Activation of P2Y₂ purinoceptor stimulates luminal cystic fibrosis transmembrane conductance regulator and basolateral Na⁺-HCO₃⁻ cotransporter-1 (NBCe1) activities through a phospholipase C (PLC)-dependent mechanism. Active cystic fibrosis transmembrane conductance regulator (CFTR) and Na⁺-HCO₃⁻ cotransporter-1 induce mucosal bicarbonate (HCO₃⁻) secretion, which reduces luminal free magnesium (Mg²⁺) and suppresses Mg²⁺ absorption. Ca²⁺: Calcium; H: Hydrogen; K: Potassium; Na⁺: Sodium.

Citation: Chamniansawat S, Suksridechacin N, Thongon N. Current opinion on the regulation of small intestinal magnesium absorption. World J Gastroenterol 2023; 29(2): 332-342
URL: https://www.wjgnet.com/1007-9327/full/v29/i2/332.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i2.332