Endoscopic and pathological characteristics of de novo colorectal cancer: Retrospective cohort study

Table 2 The endoscopic characteristics in de novo and carcinoma in adenoma groups

		De novo (n = 22)	CIA (n = 20)	χ2	P value
Budding	BD1	8 (24.2)	4 (13.3)	6.161	> 0.05
	BD2	8 (24.2)	6 (20.0)
	BD3	11 (33.3)	6 (20.0)
	None	5 (18.2)	14 (46.7)
Grading	G1	6 (18.2)	13 (43.3)	8.878	> 0.05
	G2	11 (33.3)	9 (30.0)
	G1-2	10 (30.3)	8 (26.7)
	G3-2	6 (18.2)	0 (0.0)
TIL	Yes	27 (81.8)	19 (63.3)	2.725	> 0.05
	No	6 (18.2)	11 (36.7)
Perineural infiltration	Yes	16 (48.5)	3 (10.0)	11.050	< 0.05
	No	17 (51.5)	27 (90.0)
Lymphovascular invasion	Yes	16 (48.5)	7 (23.3)	4.289	< 0.05
	No	17 (51.5)	23 (76.7)
Growth pattern	INFa	0 (0.0)	27 (90.0)	63.000	< 0.05
	INFb	0 (0.0)	3 (10.0)
	INFc	33 (100.0)	0 (0.0)
Lymph node metastasis	Yes	10 (30.3)	1 (3.3)	7.931	> 0.05
	No	23 (69.7)	29 (96.7)
Adjacent lesions	Inflammation	33 (100.0)	0 (0.0)	63.000	< 0.05
	Adenoma	0 (0.0)	17 (56.7)
	Hyperplasia	0 (0.0)	13 (43.3)
IHC-E-cadherin	No staining	0 (0.0)	0 (0.0)	22.609	< 0.05
	Weak	17 (51.5)	2 (6.7)
	Moderate	15 (48.5)	19 (63.3)
	Strong	0 (0.0)	9 (30.0)
IHC-Vimentin	No staining	0 (0.0)	0 (0.0)	23.182	< 0.05
	Weak	13 (39.4)	18 (60.0)
	Moderate	1 (3.0)	10 (33.3)
	Strong	19 (57.6)	2 (6.7)

CIA: Carcinoma in adenoma; TIL: Tumor Infiltrating Lymphocyte; IHC: Immunohistochemistry; BD: Budding grade.