Endoscopic and pathological characteristics of de novo colorectal cancer: Retrospective cohort study

Table 1 The clinical information of de novo and carcinoma in adenoma colorectal cancers

		De novo (n = 33)	CIA (n = 30)	χ2	P value
Clinical information
Age (%)	> 55	30 (90.9)	25 (83.3)	0.814	> 0.05
	< 55	3 (9.1)	5 (16.7)
Gender (%)	Male	16 (48.5)	16 (53.3)	0.148	> 0.05
	Female	17 (51.5)	14 (46.7)
Smoking history (%)	Yes	27 (81.8)	19 (63.3)	2.725	> 0.05
	No	6 (18.2)	11 (36.7)
Location (%)	Proximal	7 (21.2)	21 (70.0)	15.149	< 0.05
	Distal	26 (78.8)	9 (30.0)
Depth of invasion	M	8 (24.2)	9 (30.0)	1.504	> 0.05
	SMp	9 (27.3)	11 (36.7)
	SMd	16 (48.5)	10 (33.3)
Treatment (%)	Surgery	21 (63.6)	16 (53.3)	0.688	> 0.05
	Endoscopy	12 (36.4)	14 (46.7)
Supplement chemotherapy (%)	Yes	21 (63.6)	12 (40.0)	3.520	> 0.05
	No	12 (36.4)	18 (60.0)
Distal metastasis (%)	Yes	5 (15.2)	2 (6.7)	1.145	> 0.05
	No	28 (84.8)	28 (93.3)
Overall survival (%)	1 yr	33 (100.0)	30 (100.0)
	3 yr	30 (90.9)	28 (93.3)
	5 yr	23 (69.7)	28 (93.3)
DSS	Yes	26 (78.8)	28 (93.3)	2.715	> 0.05
	No	7 (21.2)	2 (6.7)
Endoscopic gross characteristics
Size%	1 cm < S ≤ 2 cm	14 (42.4)	9 (30.0)	30.514	< 0.05
	≤ 1 cm	16 (48.5)	0 (0.0)
	> 2 cm	3 (9.1)	21 (70.0)
Macroscopic type%	Is	5 (15.2)	6 (20.0)	35.187	< 0.05
	IIa + IIc	11 (33.3)	1 (3.3)
	IIc	17 (51.5)	4 (13.3)
	Is + IIc	0 (0.0)	19 (63.3)
Surface change	Erosion	24 (72.7)	13 (43.3)	9.457	< 0.05
	Ulceration	2 (6.1)	11 (36.7)
	None	7 (21.2)	6 (20.0)
Color change	Reddened mucosa	26 (78.8)	2 (6.7)	33.104	< 0.05
	None	7 (21.2)	28 (93.3)
NICE	Type 1	0 (0.0)	0 (0.0)		> 0.05
	Type 2	0 (0.0)	0 (0.0)
	Type 3	33 (100.0)	30 (100.0)
Sano	I	0 (0.0)	0 (0.0)	5.292	< 0.05
	II	0 (0.0)	0 (0.0)
	IIIA	17 (51.5)	7 (23.3)
	IIIB	16 (48.5)	23 (76.7)
JNET	1	0 (0.0)	0 (0.0)	3.094	> 0.05
	2A	0 (0.0)	0 (0.0)
	2B	12 (36.4)	5 (16.7)
	3	21 (63.6)	25 (83.3)
Chemical staining (crystal violet)
Pit pattern	Vi	1 (3.0)	6 (20.0)	15.774	< 0.05
	Vn	13 (39.4)	15 (50.0)
	Vi + Vn	19 (57.6)	5 (16.7)
	IV + Vi	0 (0.0)	4 (13.3)
Pit pattern at the edge of the tumors	I	33 (100.0)	0 (0.0)	63.000	< 0.05
	III + VI	0 (0.0)	30 (100.0)
Surrounding mucosa
Pulling	Yes	9 (27.3)	21 (70.0)	11.501	< 0.05
	No	24 (72.7)	9 (30.0)
Converging folds	Yes	27 (81.8)	15 (50.0)	7.159	< 0.05
	No	6 (18.2)	15 (50.0)
CSM	CSM1	11 (33.3)	4 (13.3)	3.553	> 0.05
	CSM2	17 (51.5)	21 (70.0)
	CSM3	5 (15.2)	5 (16.7)

CRC: Colorectal cancer; DSS: Disease specific survival; CSM: Chicken skin mucosa; CIA: Carcinoma in adenoma; NICE: Narrow-band imaging International Colorectal Endoscopic.