Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model

Figure 6 Complexes formed by cyclooxygenase-2 and flavonoids from Lafoensiapacari. A, C and E: Murine cyclooxygenase-2 (COX-2) bound to ellagic acid, kaempferol, and quercetin, respectively; B, D and F: Human COX-2 bound to ellagic acid, kaempferol, and quercetin, respectively. Lilac: Flavonoid; Pink: Amino acid residues; The dashed lines represent chemical interactions. The name of the amino acid is represented by the three-letter code followed by their number in the primary sequence. The numbers next to the dashed lines are the bond lengths in Angstrom.